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The Ultra-Performance Liquid Chromatography - Mass Spectrometer LC-TQ5100 is a truly domestically madetriple quadrupole mass spectrometer. Hexin Instrument experienced three stages (from technical innovationto breakthroughs in core components to industrialization of the entire instrument) to achieve domestic production of the triple quadrupole mass spectrometer by tackling key problems in three years, realizing domestic production of key components such as the high efficiency ion source, the triple quadrupole mass analyzer and high voltage radio frequency (RF) power supply. Moreover, we have applied for dozens of national invention patents and developed a triple quadrupole mass spectrometer with independent intellectual property rights.